Chemical Characteristics of Primobolan
Primobolan is a Dihydrostestosterone (DHT) derivative, landing it in the family of DHT-derivatives and analogues. Primo is a modified form of DHT, where it contains a double-bond between carbon atoms 1 and 2 in the Dihydrotestosterone structure. This is known to assist in the stabilization of the 3-keto group which in turn increases the anabolic strength of the hormone. A 1-methyl group is also added to the hormone, which is responsible for allowing the hormone to resist hepatic (liver) metabolism and breakdown. The oral format of Primobolan holds an Acetate ester chemically bonded to it, which is attached to the 17-beta-hydroxyl group on the chemical structure. This allows the oral anabolic steroid to be resistant to oxidation and hepatic breakdown through oral administration. The oral form of Primobolan has demonstrated effective oral bioavailability in studies as both in its Acetate format as well as its un-esterified format . Esterification will now be explained in more detail. The injectable format (Methenolone Enanthate) in particular is simply Methenolone with the Enanthate ester bound to the Methenolone chemical structure. Specifically, ‘Enanthate’ is Enanthoic acid (also known as carboxylic acid), but once bound to Methenolone it is properly referred to in chemistry as an ester bond (or ester linkage). Enanthoic acid is chemically bonded to the 17-beta hydroxyl group on the Methenolone structure. The addition of this ester augments the hormone’s release rate and half-life to favor a longer window of release. The primary reason for the augmentation of its half-life and release rate is because once Methenolone Enanthate enters the bloodstream, enzymes work to break the bond between the ester and the hormone, which takes a varying amount of time. The end result is that of the ester being removed from the hormone by these enzymes, and the result after this is pure Methenolone that is free to do its work in the body. This process of enzymes removing the ester from the hormone to which it is attached is what is responsible for the slower release rates. When the Enanthate ester is attached to Methenolone, creating Methenolone Enanthate, the half-life of Primobolan is now extended to 10 days, providing a slower release and activity of the hormone.
Properties of Primobolan
Primobolan being a DHT-derivative, it holds many of the same properties of its parent hormone. For example its not aromatized by the aromatase enzyme into Estrogen at any dose. Therefore, any individual looking to utilize it should never experience any Estrogen related side effects from using it alone. This means that it completely avoids the potential for any of the following side effects: water retention and bloating, elevated blood pressure (as a result of water retention), possible fat gain/retention, and gynecomastia. Without the puffy and soft look that aromatizable anabolic steroids provide the physique, Primobolan is regarded by the majority of bodybuilders and athletes as a preferred ‘cutting’ compound considered very useful for pre-contest cycles and fat loss and cutting phases. Unfortunately, because of its poor anabolic strength rating making it lower in strength than Testosterone, Primobolan is not preferred by athletes or bodybuilders for bulking cycles, lean mass cycles, or for any measurable strength gain. Primo is also best combined with (stacked with) other anabolic steroids as well, whether utilizing it for a cutting cycle or a bulking or lean mass cycle. The use of Primobolan solitarily on its own is regarded by many as a near useless practice, and along these same lines, many anabolic steroid users claim that Primo is only useful at very high doses, which may not be very practical considering the high cost of this anabolic steroid. This dosing information will be further expanded in the doses section of this profile.
Primobolan Side Effects
The first thing to understand with Primobolan is that it is a DHT-derivative, meaning it is a modified form of DHT (Dihydrotestosterone). As such, it carries with it many similar properties and characteristics, including the inability to convert (aromatize) into Estrogen at any dose used. This should certainly be a comforting fact to most individuals who are concerned about Estrogenic side effects, such as bloating, gynecomastia, high blood pressure as a result of water retention, etc. Although the oral format of Primobolan is C-17 Alpha Alkylated (also known as Methylation), which is a process that tends to make oral compounds present a degree of harm to the liver, Primobolan has never shown any measurable hepatotoxic effects to the body. Although oral Primo does not impose any measurable negative effects on the liver, it still presents some small amount of hepatotoxicity and this should still be understood, especially when it comes to extended cycle lengths and/or very high dosages. With that being said, one death of an anemic patient who was prescribed oral Primobolan has been linked to its use. Once again, high doses and/or very long cycle lengths of oral Primobolan may be a concern. As much as Primobolan is touted by athletes and bodybuilders as being a ‘mild’ anabolic steroid, it still exhibits suppression of endogenous Testosterone production and HPTA function. In fact, studies have confirmed that at even a very low dosage (30 – 45mg daily), test subjects experienced 15 – 65% suppression of natural endogenous Testosterone production. Being that those dosages as far lower than what is required for performance enhancement purposes, it is still heavily recommended to perform a proper PCT (Post Cycle Therapy) following the discontinuation of Primobolan.
Primobolan Cycles and Use
Primobolan cycles are commonly in the form of fat loss and/or cutting cycles. It is almost never used as a bulking or mass-gaining agent, and most of its use is in the form of a pre-contest drug in the final weeks leading up to a competition show or photo shoot. It is typically cycled with other compounds that hold similar qualities, properties, and half-lives. Many bodybuilders often stack Primobolan with Testosterone Propionate (or Testosterone Enanthate) and use it for the first 8 weeks of a cycle in order to assist in the retention of muscle mass during periods of low caloric intake. Other bodybuilders will perform oral Primobolan cycles stacked with compounds such as Testosterone Propionate and Trenbolone Acetate, as all of the compounds involved work synergistically especially where half-lived are concerned. Some may opt to use Primobolan (either the oral or injectable) with some form of Testosterone and Winstrol (Stanozolol), typically the injectable form if it is with the oral Primobolan. It is important to remember not to utilized two different oral compounds within the same cycle. Oral Primobolan (Methenolone Acetate) should normally be run for no longer than 8 weeks, and the injectable form (Methenolone Enanthate) can be run in cycle lengths of 10 – 12 weeks (or longer, depending on the individual’s goals and desires).